Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments. A variety of viral vectors have been tested with variable efficacy fo...

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Autors principals:	Suvarna Dash-Wagh, Stefan Jacob, Staffan Lindberg, Anders Fridberger, Ülo Langel, Mats Ulfendahl
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2012-01-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	cell-penetrating peptide (CPP) cochlea connexin FRAP gap junctions gene therapy inner ear nanoparticles siRNA
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253116301160
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