Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type
Abstract To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically matched mouse strains. Response to radiation was used as an endpoint to place findings in a b...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Nature
2025-01-01
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| coleção: | EMBO Reports |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1038/s44319-025-00375-y |
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