Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type

Abstract To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically matched mouse strains. Response to radiation was used as an endpoint to place findings in a b...

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Bibliografiske detaljer

Principais autores:	Ramy Rahmé, Lois Resnick-Silverman, Vincent Anguiano, Moray J Campbell, Pierre Fenaux, James J Manfredi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2025-01-01
Serier:	EMBO Reports
Fag:	p53 DNA Damage Radiosensitivity Gene Expression Bone Marrow
Online adgang:	https://doi.org/10.1038/s44319-025-00375-y
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