Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines. Synthetic tetra-, hexa-, and octasaccharide structurally related to CP of S. p...

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Principais autores:	Ekaterina A. Kurbatova, Nelli K. Akhmatova, Elina A. Akhmatova, Nadezhda B. Egorova, Natalya E. Yastrebova, Elena V. Sukhova, Dmitriy V. Yashunsky, Yury E. Tsvetkov, Marina L. Gening, Nikolay E. Nifantiev
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-06-01
coleção:	Frontiers in Immunology
Assuntos:	Streptococcus pneumoniae type 14 synthetic oligosaccharide glycoconjugate vaccine protective activity antibody specificity opsonophagocytosis biotinylated oligosaccharide
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00659/full
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