Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines. Synthetic tetra-, hexa-, and octasaccharide structurally related to CP of S. p...

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Hlavní autoři:	Ekaterina A. Kurbatova, Nelli K. Akhmatova, Elina A. Akhmatova, Nadezhda B. Egorova, Natalya E. Yastrebova, Elena V. Sukhova, Dmitriy V. Yashunsky, Yury E. Tsvetkov, Marina L. Gening, Nikolay E. Nifantiev
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2017-06-01
Edice:	Frontiers in Immunology
Témata:	Streptococcus pneumoniae type 14 synthetic oligosaccharide glycoconjugate vaccine protective activity antibody specificity opsonophagocytosis biotinylated oligosaccharide
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00659/full
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