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Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy

Abstract The calcium-responsive phosphatase, calcineurin, senses changes in Ca2+ concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factor CRZ1 triggered the forma...

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Principais autores: Srishti Chawla, Doryaneh Ahmadpour, Kara L. Schneider, Navinder Kumar, Arthur Fischbach, Mikael Molin, Thomas Nystrom
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-08-01
Serier:Cell Communication and Signaling
Fag:
α-synuclein
Calcineurin
Protein phosphatase 2B
Protein aggregation
Protein quality control
Online adgang:https://doi.org/10.1186/s12964-023-01242-w
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