Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy

Abstract The calcium-responsive phosphatase, calcineurin, senses changes in Ca2+ concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factor CRZ1 triggered the forma...

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Hlavní autoři:	Srishti Chawla, Doryaneh Ahmadpour, Kara L. Schneider, Navinder Kumar, Arthur Fischbach, Mikael Molin, Thomas Nystrom
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-08-01
Edice:	Cell Communication and Signaling
Témata:	α-synuclein Calcineurin Protein phosphatase 2B Protein aggregation Protein quality control
On-line přístup:	https://doi.org/10.1186/s12964-023-01242-w
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