Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy

Abstract The calcium-responsive phosphatase, calcineurin, senses changes in Ca2+ concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factor CRZ1 triggered the forma...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Srishti Chawla, Doryaneh Ahmadpour, Kara L. Schneider, Navinder Kumar, Arthur Fischbach, Mikael Molin, Thomas Nystrom
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2023-08-01
Saila:	Cell Communication and Signaling
Gaiak:	α-synuclein Calcineurin Protein phosphatase 2B Protein aggregation Protein quality control
Sarrera elektronikoa:	https://doi.org/10.1186/s12964-023-01242-w
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!