Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice

Abstract In Parkinson's disease and other synucleinopathies, fibrillar forms of α-synuclein (aSyn) are hypothesized to structurally convert and pathologize endogenous aSyn, which then propagates through the neural connections, forming Lewy pathologies and ultimately causing neurodegeneration. Inocul...

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Автори:	Tatsuhiko Sano, Tetsuya Nagata, Satoe Ebihara, Kie Yoshida-Tanaka, Ayako Nakamura, Asuka Sasaki, Aki Shimozawa, Hideki Mochizuki, Toshiki Uchihara, Masato Hasegawa, Takanori Yokota
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2024-05-01
Серія:	Acta Neuropathologica Communications
Предмети:	α-synuclein Propagation Antisense oligonucleotide Prion Parkinson’s disease Synucleinopathy
Онлайн доступ:	https://doi.org/10.1186/s40478-024-01766-3
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