S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (<it>P. anubis</it>)

<p>Abstract</p> <p>Background</p> <p>S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat β-hemoglobinopathies. In these exp...

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Detalhes bibliográficos

Principais autores:	Banzon Virryan, Singh Mahipal, Vaitkus Kestis, Saunthararajah Yogen, Lavelle Donald, Phiasivongsva Pasit, Redkar Sanjeev, Kanekal Sarath, Bearss David, Shi Chongtie, Inloes Roger, DeSimone Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2010-10-01
Colecção:	Journal of Translational Medicine
Acesso em linha:	http://www.translational-medicine.com/content/8/1/92
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