Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis).
Elevated levels of Fetal Hemoglobin interfere with polymerization of sickle hemoglobin thereby reducing anemia, lessening the severity of symptoms, and increasing life span of patients with sickle cell disease. An affordable, small molecule drug that stimulates HbF expression in vivo would be ideall...
Salvato in:
| Autori principali: | , , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2023-01-01
|
| Serie: | PLoS ONE |
| Accesso online: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289860&type=printable |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|