Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology

Abstract Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse models of beta-amyloidosis. However, the mechanisms...

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Bibliografiske detaljer

Principais autores:	Yee Fun Lee, Alyssa N. Russ, Qiuchen Zhao, Stephen J. Perle, Megi Maci, Morgan R. Miller, Steven S. Hou, Moustafa Algamal, Zhuoyang Zhao, Hanyan Li, Noah Gelwan, Zhe Liu, Stephen N. Gomperts, Alfonso Araque, Elena Galea, Brian J. Bacskai, Ksenia V. Kastanenka
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2023-08-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-023-40402-3
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