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Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta (Aβ) accumulations. Alzheimer’s patients experience sleep disturbances at early stages of the disease. APPswe/PS1dE9 (APP) mice exh...

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Principais autores: Qiuchen Zhao, Shinya Yokomizo, Stephen J. Perle, Yee Fun Lee, Heng Zhou, Morgan R. Miller, Hanyan Li, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-10-01
Serier:Scientific Reports
Fag:
Optogenetics
Astrocyte
EEG
Sleep
NREM
REM
Online adgang:https://doi.org/10.1038/s41598-024-73082-8
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