Synthesis of Substituted 1,4-Benzodiazepines by Palladium-Catalyzed Cyclization of <i>N</i>-Tosyl-Disubstituted 2-Aminobenzylamines with Propargylic Carbonates

A synthesis of substituted 1,4-benzodiazepines has been developed via palladium-catalyzed cyclization of <i>N</i>-tosyl-disubstituted 2-aminobenzylamines with propargylic carbonates. The reaction proceeds through the formation of π-allylpalladium intermediates, which undergo intramolecular nucleophi...

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Ngā kaituhi matua:	Masahiro Yoshida, Saya Okubo, Akira Kurosaka, Shunya Mori, Touya Kariya, Kenji Matsumoto
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2025-07-01
Rangatū:	Molecules
Ngā marau:	1,4-benzodiazepine cascade reaction cyclization palladium catalyst propargylic carbonate
Urunga tuihono:	https://www.mdpi.com/1420-3049/30/14/3004
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!