Assembly of Diverse 3-Methylenetetrahydrofurans via Palladium-Catalyzed Cascade Carboetherification of Buta-1,3-Dienes with Alkynols

Tetrahydrofuran scaffolds have found promising applications in both pharmaceutical chemistry and organic synthesis but remain underexplored owing to the challenges associated with their preparation. Herein, we have developed a robust synthetic strategy for the palladium-catalyzed cascade annulation...

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Main Authors: Yin-Long Lai, Yanan Niu, Kaitong Zeng, Huanfeng Jiang, Huishi Guo, Sheng-Ling Zhang, Jianxiao Li
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2025-10-01
Series:Molecules
Assuntos:
cascade cyclization
palladium catalysis
carboetherification
tetrahydrofuran heterocyclics
alkynes
Acceso en liña:https://www.mdpi.com/1420-3049/30/21/4244
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