A Novel Small-Molecule TLR7 Agonist AXC-715 Stabilizes TLR7 Dimerization and Exhibits Broad-Spectrum Antiviral Activity

Toll-like receptor 7 (TLR7) agonism offers a promising avenue for antiviral intervention. This study characterizes AXC-715, a novel small-molecule agonist that selectively targets TLR7 to elicit broad-spectrum antiviral effects. Structural analysis of the AXC-715–hTLR7 complex (PDB ID: 5GMH) elucida...

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Autores principales:	Chen Yao, Meng-Hua Du, Yan-Jie Ma, Heng Wang, Liu Hang, Zhi-Cheng Li, Hong-Yu Yang, Guo-Yu Yang, Meng-Di Wang, Sheng-Li Ming
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-04-01
Colección:	Microorganisms
Materias:	AXC-715 TLR7 dimerization NF-κB activation antiviral activity pseudorabies virus
Acceso en línea:	https://www.mdpi.com/2076-2607/14/4/862
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