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A Novel Small-Molecule TLR7 Agonist AXC-715 Stabilizes TLR7 Dimerization and Exhibits Broad-Spectrum Antiviral Activity

Toll-like receptor 7 (TLR7) agonism offers a promising avenue for antiviral intervention. This study characterizes AXC-715, a novel small-molecule agonist that selectively targets TLR7 to elicit broad-spectrum antiviral effects. Structural analysis of the AXC-715–hTLR7 complex (PDB ID: 5GMH) elucida...

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Autori principali: Chen Yao, Meng-Hua Du, Yan-Jie Ma, Heng Wang, Liu Hang, Zhi-Cheng Li, Hong-Yu Yang, Guo-Yu Yang, Meng-Di Wang, Sheng-Li Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-04-01
Serie:Microorganisms
Soggetti:
AXC-715
TLR7
dimerization
NF-κB activation
antiviral activity
pseudorabies virus
Accesso online:https://www.mdpi.com/2076-2607/14/4/862
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