Distinguishing the Concentration- vs. Bioaccumulation-Dependent Immunological and Metabolic Effects of Clofazimine

The antimycobacterial drug clofazimine (CFZ) is used as a single agent at high doses, to suppress the exaggerated inflammation associated with leprosy. Paradoxically, increasing doses of CFZ leads to bioaccumulation of CFZ in the spleen and other organs under physiologically relevant dosing regimens...

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書誌詳細

主要な著者:	Andrew R. Willmer, Jennifer Diaz-Espinosa, Austin Zhou, Kathleen A. Stringer, Gus R. Rosania
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2023-09-01
シリーズ:	Pharmaceutics
主題:	splenectomy cytokines macrophages drug targeting drug delivery
オンライン･アクセス:	https://www.mdpi.com/1999-4923/15/9/2350
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