Distinguishing the Concentration- vs. Bioaccumulation-Dependent Immunological and Metabolic Effects of Clofazimine

The antimycobacterial drug clofazimine (CFZ) is used as a single agent at high doses, to suppress the exaggerated inflammation associated with leprosy. Paradoxically, increasing doses of CFZ leads to bioaccumulation of CFZ in the spleen and other organs under physiologically relevant dosing regimens...

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Autori principali:	Andrew R. Willmer, Jennifer Diaz-Espinosa, Austin Zhou, Kathleen A. Stringer, Gus R. Rosania
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-09-01
Serie:	Pharmaceutics
Soggetti:	splenectomy cytokines macrophages drug targeting drug delivery
Accesso online:	https://www.mdpi.com/1999-4923/15/9/2350
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