Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with limited therapeutic options. The circulating metabolome comprises small molecules present in plasma/serum which are the intermediates and end-products of cellular metabolism, and is linked to ALS pathogenesis...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Elham Alhathli, Johnathan Cooper-Knock, Zain-Ul-Abideen Girach, Thomas H. Julian, Claudia Bauer, Hannah O. Timmons, Billie D. Ward, Heather Walker, Mimoun Azzouz, Mohamed A. Elrayess, Fatima Al-Khelaifi, Noha A. Yousri, Aytac Gul, Alan Kelsall, Tobias Moll, Calum Harvey, Sarah Gornall, Kari Wong, Scott P. Allen, Andrew Strange, Pamela J. Shaw
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	BMC Medicine
Schlagworte:	Amyotrophic lateral sclerosis Metabolomics Mendelian randomisation Acetylcarnitine Carnitine shuttle Cerebrospinal fluid
Online-Zugang:	https://doi.org/10.1186/s12916-026-04727-w
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