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Pyrazole-Imidazoline Derivative Prevents Cardiac Damage and Mortality in Acute <i>Trypanosoma cruzi</i> Infection

<b>Background:</b> Chagas disease poses a significant public health challenge, particularly impacting socioeconomically vulnerable populations. Current treatment strategies still rely on two nitro heterocyclic compounds: benznidazole and nifurtimox. Both agents exhibit limited therapeutic efficacy d...

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Principais autores: Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Thamyris Pérez de Souza, Vitoria Barbosa Paes, Claudia Magalhães Calvet, Liliane Batista de Mesquita, Guilherme Cury Lechuga, Cynthia Nathália Pereira, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-10-01
Serier:Pharmaceuticals
Fag:
<i>Trypanosoma cruzi</i>
Chagas disease
pyrazole
fibrosis
Online adgang:https://www.mdpi.com/1424-8247/18/10/1552
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