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Pyrazole-Imidazoline Derivative Prevents Cardiac Damage and Mortality in Acute <i>Trypanosoma cruzi</i> Infection

<b>Background:</b> Chagas disease poses a significant public health challenge, particularly impacting socioeconomically vulnerable populations. Current treatment strategies still rely on two nitro heterocyclic compounds: benznidazole and nifurtimox. Both agents exhibit limited therapeutic efficacy d...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Thamyris Pérez de Souza, Vitoria Barbosa Paes, Claudia Magalhães Calvet, Liliane Batista de Mesquita, Guilherme Cury Lechuga, Cynthia Nathália Pereira, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-10-01
Schriftenreihe:Pharmaceuticals
Schlagworte:
<i>Trypanosoma cruzi</i>
Chagas disease
pyrazole
fibrosis
Online-Zugang:https://www.mdpi.com/1424-8247/18/10/1552
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