Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against <i>Trypanosoma cruzi</i>

Chagas disease, a chronic and silent disease caused by <i>Trypanosoma cruzi</i>, is currently a global public health problem. The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited efficacy and severe side effects. The failure of...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Lorraine Martins Rocha Orlando, Guilherme Curty Lechuga, Leonardo da Silva Lara, Byanca Silva Ferreira, Cynthia Nathalia Pereira, Rafaela Corrêa Silva, Maurício Silva dos Santos, Mirian Claudia S. Pereira
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	MDPI AG 2021-11-01
سلاسل:	Molecules
الموضوعات:	<i>Trypanosoma cruzi</i> pyrazole derivatives trypanocidal activity 3D culture model
الوصول للمادة أونلاين:	https://www.mdpi.com/1420-3049/26/21/6742
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!