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Pediatric tumor microenvironment: developmental dynamics and therapy resistance

The tumor microenvironment (TME) in pediatric cancers is profoundly shaped by the unique biological context of childhood development. Unlike adult tumors, pediatric malignancies arise in growing tissues, where evolving immune systems, dynamic stromal elements, and distinct hormonal and microbial inf...

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Principais autores: Noreen Grace George, Bhavika Rishi, Himanshu Dhanda, Gratial Theres Joseph, Sandeep Kumar Swain, Manpreet Kaur, Neetu Kushwaha, Raj Kamal, Pranay Tanwar, Sufian Zaheer, Shamsuz Zaman, Amitabh Singh, Fouzia Siraj, Aroonima Misra
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-11-01
Series:Frontiers in Oncology
Assuntos:
pediatric tumor microenvironment
therapeutic resistance
immune checkpoint inhibition
ECM
developmental oncology
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fonc.2025.1663975/full
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