Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients

BackgroundThiopurines such as 6-mercaptopurine (6-MP) are central to maintenance therapy for pediatric acute lymphoblastic leukemia (ALL), yet their narrow therapeutic index frequently causes dose-limiting myelosuppression in genetically susceptible patients. Variants in NUDT15 and TPMT are major ph...

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Principais autores:	Gratial Theres Joseph, Sandeep Kumar Swain, Tejas Somwanshi, Aarishi Singh, Manpreet Kaur, Raj Kamal, Himanshu Dhanda, Prashant Kumar, Upasana Kaushik, Baseer Noor, Saurabh Sharma, Pranay Tanwar, Sufian Zaheer, Sumita Chaudhry, Prashant Prabhakar, Amitabh Singh, Bhavika Rishi, Aroonima Misra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
Colecção:	Frontiers in Pharmacology
Assuntos:	acute lymphoblastic leukemia (ALL) thiopurine toxicity NUDT15 c.415C>T TPMT*3C Pharmacogenetics ARMS-PCR
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1714797/full
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