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Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein

<p>Abstract</p> <p>Background</p> <p>Retroviruses HTLV-1 and HTLV-2 have homologous genomic structures but differ significantly in pathogenicity. HTLV-1 is associated with Adult T cell Leukemia (ATL), whereas infection by HTLV-2 has no association with neoplasia. Transformation of T lymphocytes by H...

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Hlavní autoři: Turci Marco, Lodewick Julie, Di Gennaro Gianfranco, Rinaldi Anne, Marin Oriano, Diani Erica, Sampaio Carla, Bex Françoise, Bertazzoni Umberto, Romanelli Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2012-12-01
Edice:Retrovirology
Témata:
HTLV-1
HTLV-2
Retrovirus
Tax
Oncoprotein
Leukemia
Post-translational modification
Ubiquitination
Sumoylation
NF-κB pathway
On-line přístup:http://www.retrovirology.com/content/9/1/102
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