Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
Abstract NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological processes. NEDD8-activating enzyme (NAE) as the only activation enzyme in the NEDDylation modification has become an attractive target to develop...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2023-07-01
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| coleção: | Journal of Hematology & Oncology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13045-023-01485-7 |
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