Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4–DTL–p21/p53 axis in nasopharyngeal carcinoma

Abstract Background Nasopharyngeal carcinoma (NPC) continues to represent a significant therapeutic challenge. Despite the substantial success of radiotherapy, chemotherapy, and immunotherapy, their effectiveness remains limited in recurrent or advanced NPC. Hence, the urgent identification of new m...

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Hauptverfasser:	Cong-Chao Jia, Zhen-Yi Li, Wei-Hua Jia, Cheng-Tao Jiang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	Hereditas
Schlagworte:	Nasopharyngeal carcinoma DTL Pevonedistat Machine learning Molecular docking PDX models
Online-Zugang:	https://doi.org/10.1186/s41065-026-00661-2
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