Evaluation of galantamine and deconstructed analogs as α7 nAChR and AChE ligands

Galantamine (1), one of only five agents currently approved for the treatment of Alzheimer’s disease, is thought to act primarily as an inhibitor of acetylcholinesterase (AChE) and possibly as a positive allosteric modulator (PAM) of neuronal α7 nicotinic acetylcholine (nACh) receptors. Here, the st...

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Prif Awduron:	Malaika D. Argade, Laura DeCristofano, Nirajan Bhattarai, Marvin K. Schulte, Malgorzata Dukat
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2022-01-01
Cyfres:	Results in Chemistry
Pynciau:	Galantamine Lycoramine SAR α7 nAChRs AChE
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2211715622000054
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!