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Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (CTD) of VxXXB bound to Lymnea stagnalis acetylcholine binding...

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Principais autores: Thao NT Ho, Nikita Abraham, Richard J. Lewis
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-04-01
Serier:Frontiers in Pharmacology
Fag:
α-conotoxin
α7 nAChR
pharmacology
AChBP
allosteric
granulin fold
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1170514/full
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