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Inhibiting CXCR6 promotes senescence of activated hepatic stellate cells with limited proinflammatory SASP to attenuate hepatic fibrosis

This study investigates the previously unexplored role of CXC chemokine receptor 6 (CXCR6) in hepatic fibrosis, where excessive extracellular matrix deposition by activated hepatic stellate cells (aHSCs) drives disease progression. Through analysis of gene expression omnibus datasets and human fibro...

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Principais autores: Sheng Liqin, Wu Yiming, Shen Fei, Xu Chenzhou
Format: Artigo
Sprog:Inglês
Udgivet: De Gruyter 2025-08-01
Serier:Open Life Sciences
Fag:
hepatic stellate cells
senescence
sasp
cxcr6
hepatic fibrosis
Online adgang:https://doi.org/10.1515/biol-2025-1151
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