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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Recent studies suggest key roles of RNA in DNA double-strand breaks repair. Here the authors identify the helicase senataxin to be involved in DNA repair and resolve RNA:DNA hybrids forming at DNA double-strand breaks.

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Autori principali: Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, Gaëlle Legube
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2018-02-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-018-02894-w
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