Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs

Abstract Background Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. Methods Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and mutational status of DNA-PK and ATM, were analyzed...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Cholpon S. Djuzenova, Thomas Fischer, Astrid Katzer, Dmitri Sisario, Tessa Korsa, Gudrun Steussloff, Vladimir L. Sukhorukov, Michael Flentje
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2021-11-01
Schriftenreihe:	BMC Cancer
Schlagworte:	DNA damage DNA-PK Histone γH2AX p53 Radiation sensitivity
Online-Zugang:	https://doi.org/10.1186/s12885-021-08930-1
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!