Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks
Background: Ascorbate is used for combination therapy with promising results in clinical trials. The proposed main ascorbate cytotoxic effect is DNA damage induction through excessive oxidative stress. However, the involvement of DNA double-strand breakage (DSB) formation and repair in ascorbate-ind...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2025-10-01
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| Серии: | Heliyon |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S240584402502359X |
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