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Thermal Stability as a Determinant of AAV Serotype Identity

Currently, there are over 150 ongoing clinical trials utilizing adeno-associated viruses (AAVs) to target various genetic diseases, including hemophilia (AAV2 and AAV8), congenital heart failure (AAV1 and AAV6), cystic fibrosis (AAV2), rheumatoid arthritis (AAV2), and Batten disease (AAVrh.10). Prio...

Celý popis

Uloženo v:
Hlavní autoři: Antonette Bennett, Saajan Patel, Mario Mietzsch, Ariana Jose, Bridget Lins-Austin, Jennifer C. Yu, Brian Bothner, Robert McKenna, Mavis Agbandje-McKenna
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017-09-01
Edice:Molecular Therapy: Methods & Clinical Development
Témata:
adeno-associated virus
AAV
AAV capsid stability
AAV serotype identification
AAV vector buffers
AAV buffer formulations
differential scanning fluorimetry
parvovirus stability
viral vectors
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2329050117300864
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