Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs
OmIA, isolated from Conus omaria venom, is a potent antagonist at α7 nAChRs. We determined the co-crystal structure of OmIA with Lymnae stagnalis acetylcholine binding protein (Ls-AChBP) that identified His5, Val10 and Asn11 as key determinants for the high potency of OmIA at α7 nAChRs. Remarkably,...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2021-12-01
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| Schriftenreihe: | Frontiers in Pharmacology |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fphar.2021.803397/full |
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