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The RP11-417E7.1/THBS2 signaling pathway promotes colorectal cancer metastasis by activating the Wnt/β-catenin pathway and facilitating exosome-mediated M2 macrophage polarization

Abstract Background Metastasis is the major cause of colorectal cancer (CRC) mortality. Emerging evidence suggests that long noncoding RNAs (lncRNAs) drive cancer metastasis and that their regulatory pathways could be targeted for preventing metastasis. However, the underlying mechanisms of lncRNAs...

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Principais autores: Yunze Liu, Heng Lv, Xin Liu, Lei Xu, Tiankang Li, Hui Zhou, Hongmei Zhu, Chuanchuan Hao, Changwei Lin, Yi Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-07-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
RP11-417E7.1
Colorectal cancer
Metastasis
Macrophage polarization
Wnt/β-catenin
Netropsin
Acesso em linha:https://doi.org/10.1186/s13046-024-03107-7
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