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A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator

The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionaril...

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Furkejuvvon:
Váldodahkkit: Fatih M. Uckun, Hong Ma, Zahide Ozer, Patricia Goodman, Jian Zhang, Sanjive Qazi
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2014-11-01
Ráidu:EBioMedicine
Fáttát:
Cell cycle
Tyrosine kinase
Phosphatase
Checkpoint control
Genomic instability
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2352396414000218
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