A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator

The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionaril...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Fatih M. Uckun, Hong Ma, Zahide Ozer, Patricia Goodman, Jian Zhang, Sanjive Qazi
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2014-11-01
Цуврал:	EBioMedicine
Нөхцлүүд:	Cell cycle Tyrosine kinase Phosphatase Checkpoint control Genomic instability
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2352396414000218
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!