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Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies

Epithelial ovarian cancer (EOC) remains one of the leading causes of cancer-related deaths among women worldwide. Receptor tyrosine kinases (RTKs) have long been sought as therapeutic targets for EOC, as they are frequently hyperactivated in primary tumors and drive disease relapse, progression, and...

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Principais autores: Ying Wei, Sonia Erfani, David Schweer, Rafael de Gouvea, Javeria Qadir, Junfeng Shi, Kai Cheng, Dabao Wu, Rolf Craven, Yadi Wu, Thibault Olivier, Lauren A. Baldwin, Binhua Zhou, Ying Zhou, Weidong Zhao, Burton B. Yang, Frederick R. Ueland, Xiuwei H. Yang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-03-01
Serier:Molecular Therapy: Oncolytics
Fag:
ovarian cancer
receptor tyrosine kinases
EGFR
ERBB2
MET
VEGFR
Online adgang:http://www.sciencedirect.com/science/article/pii/S2372770523000141
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