Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase
Abstract Vitamin K-dependent (VKD) carboxylation, mediated by γ-glutamyl carboxylase (GGCX), is essential for the maturation of VKD proteins involved in critical physiological processes such as blood clotting, vascular calcification and bone metabolism. Here, we present cryo-electron microscopic str...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-11-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-025-65488-3 |
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