Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection

Abstract Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function during ageing. However, the impact of ageing on macropha...

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Detalhes bibliográficos

Principais autores:	Thurid Lauf, Antje Häder, Franziska Hornung, Yasmina Reisser, Sandor Nietzsche, Fabian Schanz, Verena Trümper, Aldona Jeznach, Sascha Brunke, Torsten Doenst, Tomasz Skirecki, Bettina Löffler, Stefanie Deinhardt-Emmer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-11-01
coleção:	Immunity & Ageing
Assuntos:	Influenza A virus Mitochondria cGAS-STING pathway Ageing Macrophages
Acesso em linha:	https://doi.org/10.1186/s12979-024-00482-9
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