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Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length

ObjectiveThis study speculates that gestational diabetes mellitus (GDM) may reduce fetal telomere length (TL),which may be related to modification of methylation in the promoter region of the telomerase (TE) gene promoter region.MethodsIn this study, umbilical cord blood samples from patients with a...

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Principais autores: Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Bin Zhang, Xianxia Chen, Mingming Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-03-01
coleção:Frontiers in Endocrinology
Assuntos:
gestational diabetes mellitus
telomere length
telomerase
TERT
TERC
methylation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fendo.2025.1502329/full
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