Fecal bile acid dysmetabolism and reduced ursodeoxycholic acid correlate with novel microbial signatures in feline chronic kidney disease

BackgroundMicrobial-derived secondary bile acids (SBAs) are reabsorbed and sensed via host receptors modulating cellular inflammation and fibrosis. Feline chronic kidney disease (CKD) occurs with progressive renal inflammation and fibrosis, mirroring the disease pathophysiology of human CKD patients...

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Principais autores:	John C. Rowe, Stacie C. Summers, Jessica M. Quimby, Jenessa A. Winston
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-10-01
Serija:	Frontiers in Microbiology
Teme:	bile acid inducible (bai) operon chronic kidney disease (CKD) 7α-dehydroxylation Peptacetobacter hiranonis Oscillospirales ursodeoxycholic acid
Online dostop:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1458090/full
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