Acute gastrointestinal graft-versus-host disease is associated with reductions of secondary bile acids following allogeneic hematopoietic cell transplantation

IntroductionAllogeneic hematopoietic cell transplantation (HCT) can cure hematologic malignancies, but 30-70% of recipients experience acute graft-versus-host disease (GvHD). GvHD is associated with perturbations in the gut microbiome. Bile acids are host derived compounds that are transformed by gu...

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Principais autores:	Robin Cagle, Sean Proll, Samuel S. Minot, Hayley Purcell, Wentao Zhu, Danijel Djukovic, Congzhou Liu, Tina Fiedler, Martha DeMeules, Marco Mielcarek, Sujatha Srinivasan, Daniel Raftery, Michael Wu, Steven A. Pergam, David N. Fredricks
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
Colecção:	Frontiers in Microbiology
Assuntos:	bai operon bile acid metabolism bile salt hydrolase graft-versus-host disease gut microbiome hematopoietic cell transplant
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1818647/full
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