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Discovering non-additive heritability using additive GWAS summary statistics

LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-wide association study (GWAS) summary statistics alone, making it a fast and popular approach. In this work, we present interaction-LD score (i-LDSC) regression: an extension of the original LDSC framework that...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Samuel Pattillo Smith, Gregory Darnell, Dana Udwin, Julian Stamp, Arbel Harpak, Sohini Ramachandran, Lorin Crawford
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2024-06-01
Rangatū:eLife
Ngā marau:
interactions
summary statistics
non-additive effects
heritability
Urunga tuihono:https://elifesciences.org/articles/90459
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