PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
Abstract Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune PRS models using summary stat...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2021-09-01
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| Serie: | Genome Biology |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s13059-021-02479-9 |
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