X-inactive specific transcript (XIST) can determine sex differences in cardiovascular drug responses: focus on RNA therapeutics

Genetic, hormonal, anatomical, and environmental factors underlie sex differences in the prevalence and progression of cardiovascular disease and responses to therapeutics. The presence of two X chromosomes in the female genome decreases susceptibility to X-linked recessive disorders but imposes the...

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Bibliografische Detailangaben

Hauptverfasser:	Timur O. Yarovinsky, Vinod S. Ramgolam, Iva R. Knezevic, Nina S. Stachenfeld, Jeffrey R. Bender
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-01-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	cardiovascular diseases miRNA RNA therapeutics sex as a biological variable (SABV) X chromosome inactivation (XCI) XIST (X-inactive specific transcript)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1716863/full
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