Synthesis of Novel Gefitinib-Conjugated 1,2,3-Triazole Derivatives and Their Effect of Inducing DNA Damage and Apoptosis in Tumor Cells

Compounds with rigid planar structures can insert into tumor cell DNA, thereby inducing DNA damage in tumor cells. In this study, quinazoline, a compound with a planar structure, was used as the core scaffold. A rigid planar 1,2,3-triazole moiety was introduced into its structure, and its activity w...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Junfei Wu, Xu Huang, Shan Lu, Ziyi Wang, Longfei Mao, Sanqiang Li
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2024-11-01
Sarja:	Molecules
Aiheet:	rigid planar structures quinazoline 1,2,3-triazole DNA damage HepG2 cells
Linkit:	https://www.mdpi.com/1420-3049/29/22/5438
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