Synthesis of Novel Gefitinib-Conjugated 1,2,3-Triazole Derivatives and Their Effect of Inducing DNA Damage and Apoptosis in Tumor Cells

Compounds with rigid planar structures can insert into tumor cell DNA, thereby inducing DNA damage in tumor cells. In this study, quinazoline, a compound with a planar structure, was used as the core scaffold. A rigid planar 1,2,3-triazole moiety was introduced into its structure, and its activity w...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Junfei Wu, Xu Huang, Shan Lu, Ziyi Wang, Longfei Mao, Sanqiang Li
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2024-11-01
Цуврал:	Molecules
Нөхцлүүд:	rigid planar structures quinazoline 1,2,3-triazole DNA damage HepG2 cells
Онлайн хандалт:	https://www.mdpi.com/1420-3049/29/22/5438
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!